INTRODUCTION

Purpose: To review and reinforce your knowledge of the reactions of glycolysis, gluconeogenesis, the pentose phosphate pathway and the tricarboxylic acid (Krebs) cycle, as well remind you about some vitamin-coenzyme connections.

 

Recall Objectives:

 

1. Know the "bottom lines" of glycolysis, gluconeogenesis, pentose phosphate, the TCA cycle and the pyruvate dehydrogenase reaction.
2. Reason from the pathways in clinical contexts and recognize the key regulatory steps in these pathways.
3. Recognize why the intermediates -- and the enzymes that act on them -- have the names that they do.
4. Apply knowledge of the pathways to clinical situations.
5. Describe the following reactions:
   Hexokinase Phosphofructokinase-1 Glyceraldehyde 3-phosphate dehydrogenase Pyruvate kinase Pyruvate dehydrogenase Isocitrate dehydrogenase α-ketoglutarate dehydrogenase Succinate dehydrogenase Glucose 6-phosphate dehydrogenase Pyruvate carboxylase Fructose 1,6-bisphosphatase Glucose 6-phosphatase
6. Identify the four functions of the pentose phosphate pathway.
7. Associate coenzymes with the vitamins from which they are produced and list reactions these coenzymes participate in.
8. Distinguish between the concepts of coenzyme and vitamin.
9. Recognize why compounds -- and the enzymes that act on them -- have the names they do.

 

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