One-carbon Metabolism: Basic Concepts, continued

 

VITAMIN B₁₂ (COBALAMIN)

Vitamin B₁₂ is an essential nutrient we all need in our diet.

• Corrin ring
• Cobalt center with six ligands:   four nitrogens from corrin ring, nitrogen from Benzimidazole and a variable sixth ligand
• Sixth ligand can be one of the following:
• Cyano
• Methyl
• Hydroxy
• 5'-Deoxyadenosine (Coenzyme B₁₂)
• Various oxidation states of cobalt and ability to form a Cobalt-carbon bond are important for its function.

 

 

Check Your Knowledge

 

 

 

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