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Question:

How is gluconeogenesis different?

Answer:

Up until now, all the "bottom lines" had to do with what a cell does that is best for its own survival. Gluconeogenesis is different it is something one cell does for another, specifically what the liver does for the brain, RBC's and actively exercising muscle.
The brain requires a certain concentration of glucose in the blood in order to continue to function. RBC's have an absolute requirement for glucose, as mentioned above. The liver's job is to make sure that levels of blood glucose are sufficiently maintained to support brain and RBC function. For this purpose it requires gluconeogenesis, a pathway that allows it to make glucose from pyruvate.